Table 1. Clinical characteristics and immunology of patients with laryngeal cryptococcosis.

	Case 1	Case 2	Case 3
Characteristic
Age (years)	67	69	81
Sex	Male	Male	Male
Main comorbidities	Liver transplant	Diabetes mellitus	Pulmonary Langerhans cell histiocytosis.
Inhaled corticosteroids	No	No	Yes
HIV infection	No	No	No
Clinical findings	Hoarseness	Hoarseness, dysphagia, shortness of breath, productive cough, and weight loss	Hoarseness, cough, weight loss
Type of lesion	Vegetative	Granulomatous	Granulomatous
Serum cryptococcal antigen	Negative	Negative	Negative
Treatment	Liposomal amphotericin-B, followed by fluconazole	Liposomal amphotericin-B, followed by fluconazole	Fluconazole
Outcomes	Clinical improvement	Clinical stability	Clinical improvement
Immunology
CD1a	Negative	Very scarce	Very scarce
S100 protein	Negative	Negative	Scarce
CD68	Abundant	Abundant	Abundant
CD56	Very scarce	Very scarce	Very scarce
IL-17	Negative	Scarce	Scarce
Tbet	Negative	Negative	Mild
TNF-α	Scarce	Mild	Mild
IFN-γ	Negative	Scarce	Negative
GATA3	Mild	Mild	Mild