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Effect of subcutaneous adenovirus administration on duration of hAAT expression. Shown are the group average serum hAAT concentrations at various times following transduction of two groups of C3H mice with 3 × 109 PFU of Ad/RSVhAAT via a portal vein catheter and subcutaneous administration of either saline or 2 × 109 PFU of Ad/RSVhAAT at the base of the tail. Shown is one of three separate experiments with similar results. The vertical bars represent standard deviations.
