TABLE 1.

Anti-hAAT and adenovirus neutralizing antibodies for mice represented in Fig. 1A

Strain	Day 56 serum hAAT (ng/ml)	Serum anti-hAAT IgG at 8 wka		Adenovirus neutralizing antibody titerb
		Dilution of 1:1,000	Dilution of 1:10,000	8 wk	12 wk
C3H	773, 994, <50	+++, +++, +++	+, +, ++	16, 64, 16	16, 64, 16
B6	1,440, 2,049, 1,553	−, +, −	−, −, −	≤16, 16, 64	64, 64, 64
Balb/c	<50, <50, <50, <50	++, ++, ++, +	+, +, −, −	—, 16, 64, 16	—, 16, 16, 64
Balb/b	1,113, 1,642, 400, 1,039	−, −, −, −	−, −, −, −	≤16, 64, 16, —	16, 64, 16, —

^aQualitatively reported for each animal in comparison to a standard curve of anti-hAAT monoclonal antibody (MAb) as follows: −, not detected; +, detected at level similar to that of standard MAb diluted >1:1,000; ++, detected at level similar to that of standard MAb diluted ≥1:100; or +++, detected at level greater than the lowest dilution of MAb standard. The order of the data is the same within each group. —, insufficient sample to perform the test. 

^bExpressed as the median reciprocal (1/x) dilution yielding 75% neutralization. Values of ≤16 indicate that antibodies were detected but resulted in less than 75% neutralization at a 1:16 dilution.