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. 2023 Oct 19;42(7):1107–1117. doi: 10.1038/s41587-023-01945-y

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© Genentech, Inc. and Adaptive Biotechnologies Corp. 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Workflow for untargeted immunopeptidomic analysis of monoallelic cell lines containing the polyantigen cassette. b, Number of unique 8–11-mer peptides identified in untargeted immunopeptidomic analysis. The box represents the interquartile range; the line represents the median value; and the whiskers represent the minimum and maximum values (excluding outliers). Each dot represents a separate analysis beginning with a replicate cell pellet (A*01:01 n = 6, A*02:01 n = 13, A*03:01 n = 8, A*11:01 n = 6, A*24:02 n = 4, B*07:02 n = 4, B*08:01 n = 4, B*35:01 n = 2, B*51:01 n = 2, C*03:04 n = 2, C*04:01 n = 4, C*05:01 n = 4, C*06:02 n = 4, C*07:01 n = 4, C*07:02 n = 4, HLAKO n = 5). c, Identified shared cancer neoantigen epitopes. The color scale represents the log₁₀ largest area across all analyses. d, Comparison of TR-FRET RZ-score and NetMHC EL percentile rank (%Rank) score for each epitope identified through untargeted immunopeptidome analysis. a was created with BioRender.com.