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. 2024 Jul 3;15:1404119. doi: 10.3389/fphar.2024.1404119

FIGURE 1.

FIGURE 1

LRE preserved RGC function in the eyes of the laser-induced COH and DBA/2J mice without affecting the elevated IOP. (A) A schematic representation of the experimental flows in the laser-induced COH mouse model (upper lane) and the DBA/2J mouse strain (lower lane) (Diagram is created in BioRender.com). (B) IOP measurement on the awake mice in the laser-induced COH mice after 30 days of laser photocoagulation. (C) IOP measurement on the anesthetized C57BL/6J and DBA/2J mice at the age of 10 months. (D–G) Representative ERG waves were shown on the assessment of RGC function using a photopic ERG test with flash strengths of 3.0 and 10.0 cd s.m-2 in the laser-induced COH, DBA/2J, and control eyes after LRE treatment. (H–K) Bar chart figures demonstrated that LRE oral feeding significantly increased the PhNR amplitudes in the COH eyes at photopic 10.0 cd s.m-2 and in the DBA/2J mice eyes at photopic 3.0 cd s.m-2. *, p < 0.05; **, p < 0.01; ***, p < 0.001; n. s., not significant.