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. 2024 Jul 3;15:1404119. doi: 10.3389/fphar.2024.1404119

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Copyright © 2024 Liu, Zhou, Wu, Chen, Zheng, Wang, So, Ma, Wang and Chiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LRE inhibited apoptosis in the RGC layer of the laser-induced COH and DBA/2J mice. (A) Representative images of caspase-3 positive cells (red, arrows) in the retinal sections from the normal, water-fed, and LRE-fed COH mice. Scale bar, 25 µm. (B) LRE significantly decreased the number of caspase-3 positive cells in the RGC layer of the COH eyes. (C) Representative images of caspase-3 positive cells (red, arrows) in the retinal sections from the C57BL/6J control, water-fed, and LRE-fed DBA/2J mice. Scale bar, 25 µm. (D) LRE significantly decreased the number of caspase-3 positive cells in the RGC layer of the DBA/2J mice. *, p < 0.05; ***, p < 0.001.