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. 2024 Jul 3;15:1404119. doi: 10.3389/fphar.2024.1404119

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Copyright © 2024 Liu, Zhou, Wu, Chen, Zheng, Wang, So, Ma, Wang and Chiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LRE affected microglial activation in the retina of the laser-induced COH eyes. (A) Representative images of Iba-1 positive cells (red, arrows) in the retinal sections from the normal, water-fed, and LRE-fed COH mice. Scale bar, 25 µm. (B) LRE significantly decreased the number of Iba-1 positive microglia in the retina of COH eyes. (C) The gene expressions of IL-1β, IL-6, IL-10, and CX3CR1 in the retina of normal, water-fed, and LRE-fed COH eyes. (D) Representative images of Iba-1 positive cells (red, arrows) in the retinal sections from the C57BL/6J, water-fed, and LRE-fed DBA/2J mice. Scale bar, 25 µm. (E) LRE did not change the Iba-1 positive microglial cell number in the retina of DBA/2J mice. *, p < 0.05; **, p < 0.01; ***, p < 0.001.