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. 2023 Sep 7;42(7):1133–1149. doi: 10.1038/s41587-023-01934-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, Bar plots of Signal-to-Noise Ratio (SNR) of horizontal integration of all batches of methylation, miRNAseq, RNAseq, proteomics, and metabolomics datasets at absolute level (Blue) and ratio level (Red) with the choice of different Quartet samples as the reference sample. b-d, PCA plots of horizontal integration of omics datasets at ratio level by scaling to D5 (b), F7 (c), and M8 (d).