FIG. 3.

Serum antibody responses in mice immunized parenterally with the indicated VLPs in Freund’s adjuvant. The serum antirotavirus antibody titers were assayed by ELISA (five mice per group); the GMTs determined for mice twice immunized 28 dpi (solid bar) and 42 dpi (hatched bar) or three times immunized 114 dpi (white bar) are compared. Statistical increases (P < 0.05) in GMTs in each of the groups are indicated by the same symbol (■ or ⧫). The error bars represent 1 standard error of the mean.