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Synthesis of the target compounds 15a‒h and 16. Reagents and conditions: (i) K2CO3, DMF, r.t., 90% yield; (ii) (EtO)2P(O)CH2CN, t-BuOK, THF, 0 °C to rt, 84% yield; (iii) K2CO3, DMF, 120 °C; TFA, DCM, r.t., 75% yield; (iv) K2CO3, DMF, r.t., 88% yield; (v) Pd2(dba)3, Xantphos, Cs2CO3, 1,4-dioxane, 90 °C, 55%–68% yield; (vi) Me3SiBr, acetonitrile, 0–80 °C, 63% yield.
