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Inhibitory activity against WT HIV-1 RT of 9a‒c and 15a.
| Compd. | IC50 (μmol/L)a | Compd. | IC50 (μmol/L)a |
|---|---|---|---|
| 9a | 0.31 ± 0.01 | 9b | 0.35 ± 0.05 |
| 9c | 0.76 ± 0.15 | 15a | 0.34 ± 0.09 |
| NVP | 0.43 ± 0.16 | EFV | 0.01 ± 0.00 |
| ETR | 0.01 ± 0.00 | RPVb | 0.02 ± 0.00 |
IC50: inhibitory concentration of test compound required to inhibit biotin deoxyuridine triphosphate (biotindUTP) incorporation into WT HIV-1 RT by 50%.
The data were obtained from the same laboratory with the same method.
