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Pharmacokinetic profiles of 15a·HCla.
| Subject | t1/2 (h) | Tmax (h) | Cmax (ng/mL) | AUC0‒t (h·ng/mL) | AUC0‒∞ (h·ng/mL) | CL (mL/min/kg) | F (%) |
|---|---|---|---|---|---|---|---|
| 15a·HCl (iv)b | 0.60 ± 0.03 | 0 ± 0.00 | 1785 ± 50.9 | 635 ± 9.85 | 640 ± 10.3 | 52.1 ± 0.82 | – |
| 15a·HCl (po)c | 1.32 ± 0.13 | 2.00 ± 0.00 | 333 ± 58.3 | 1270 ± 307 | 1303 ± 322 | – | 40.8 |
PK parameters (mean ± SD, n = 3).
Dosed intravenously at 2 mg/kg.
Dosed orally at 10 mg/kg.
