Figure 6.

Drug‒target‒ADR association diagram for Pergolide. The left table enumerates the known targets of the drug, while the right table lists the predicted off-targets along with their respective probability values. Targets with a blue background represent overlapping targets between predicted and known targets. Side effect descriptions associated with each target are provided adjacent to them, with arrows indicating the corresponding ADRs of Pergolide. Colored ADRs are linked to predicted new targets. (e.g., Cardiotoxicity is marked in red, corresponding to “↑ in HR”, “tachycardia”, “↑heart failure” and so on in the target's side effect description; Insomnia is marked in purple, corresponding to “insomnia” and “↓sleep” in the target's side effect description). BP: blood pressure; HR: heart rate; GI: glycemic index; PR interval: the time from the beginning of the P wave (atrial depolarization) to the beginning of the QRS complex (ventricular depolarization).