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. 2024 Jul 25;42(19):3931–3937. doi: 10.1016/j.vaccine.2024.05.067

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© 2024 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — COVID-19 vaccine effectiveness^a against medically-attended symptomatic SARS-CoV-2 infection among target groups for vaccination, (A) overall against any SARS-CoV-2 and against Omicron XBB and its sublineages and (B) against any SARS-CoV-2 stratified by age-specific vaccination target groups, Europe, VEBIS primary care study, September 2023–January 2024. Abbreviations: VEBIS: Vaccine Effectiveness, Burden and Impact Studies. The series of numbers below the x-axes provides the number of vaccinated cases; number of cases / number of vaccinated controls; number of controls. ^a All VE models included study site, sex and presence of chronic condition as adjustment variables. Using the Akaike information criterion to select the best functional form of onset date and age for each VE model, we included onset date as a restricted cubic spline (RCS) with 3 or 4 knots depending on the analysis, and age as a RCS with 3 or 5 knots, as a continuous variable or as a categorical variable with 5-year age bands depending on the analysis. ^b The target groups for older adults varied by country, see Table 1.

Fig. 2 — COVID-19 vaccine effectiveness^a against medically-attended symptomatic SARS-CoV-2 infection among target groups for vaccination, (A) overall against any SARS-CoV-2 and against Omicron XBB and its sublineages and (B) against any SARS-CoV-2 stratified by age-specific vaccination target groups, Europe, VEBIS primary care study, September 2023–January 2024. Abbreviations: VEBIS: Vaccine Effectiveness, Burden and Impact Studies. The series of numbers below the x-axes provides the number of vaccinated cases; number of cases / number of vaccinated controls; number of controls. ^a All VE models included study site, sex and presence of chronic condition as adjustment variables. Using the Akaike information criterion to select the best functional form of onset date and age for each VE model, we included onset date as a restricted cubic spline (RCS) with 3 or 4 knots depending on the analysis, and age as a RCS with 3 or 5 knots, as a continuous variable or as a categorical variable with 5-year age bands depending on the analysis. ^b The target groups for older adults varied by country, see Table 1.