Table 1:
Detailed characteristics of all patients with posttransplant C3 glomerulopathy (reference for serum C3 levels: 90–180 mg/dL).
| Patient | Sex | Primary disease | Family history | Age at KTx | Donor type | Post-KTx Diagnosis |
Age at post-KTx diagnosis |
Time from KTx to diagnosis (months) |
Biopsy indication |
Endocapillary proliferation |
Percentage of cellular and/or fibrocellular crescents |
Interstitial inflammation |
Percentage of sclerotic glomeruli |
Interstitial fibrosis |
Tubular atrophy |
SCr at diagnosis (mg/dL) | Serum C3 at diagnosis (mg/dL) |
SCr 1 year after diagnosis (mg/dL) |
Time from diagnosis to last follow-up (months) |
Treatment | Remission | Graft loss |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | C3G | None | 38 | Living | C3G | 40 | 24 | Graft dysfunction and hematuria | No | 0 | Yes | 16.7 | Mild | Mild | 2.10 | 81 | 1.30 | 33 | ECZ | CR | No |
| 2 | F | C3G | None | 46 | Living | C3G | 49 | 28 | Proteinuria and hematuria | No | 14.3 | Yes | 0 | None | None | 1.60 | 89 | 1.36 | 32 | ECZ | CR | No |
| 3 | F | C3G | KTx in aunt | 21 | Living | DDD | 21 | 7 | Proteinuria and hematuria | No | 18.2 | Yes | 9.1 | Mild | Mild | 1.35 | 15 | 0.97 | 15 | ECZ | NR | No |
| 4 | M | Unknown | None | 36 | Living | C3G | 45 | 109 | Graft dysfunction, proteinuria and hematuria | No | 10 | Yes | 25 | Mild | Mild | 3.00 | 56 | Graft loss | 4 | ECZ | NR | Yes |
| 5 | M | MPGN | None | 25 | Living | C3G | 29 | 48 | Proteinuria and hematuria | No | 0 | Yes | 40 | None | Mild | 1.39 | 81 | 3.28 | 16 | ECZ | NR | Yes |
| 6 | M | MPGN | None | 25 | Living | C3G | 36 | 139 | Graft dysfunction | No | 0 | No | 20 | Mild | Moderate | 3.50 | NA | Graft loss and re-KTx | 97 | None | NA | Yes |
| 7 | F | C3G | None | 36 | Deceased | C3GN | 43 | 77 | Graft dysfunction and proteinuria | Yes | 3.2 | Yes | 12.9 | Mild | Mild | 1.80 | NA | 2.50 | 67 | ECZ | NR | Yes |
| 8 | M | C3G | None | 29 | Living | C3G | 29 | 1 | Graft dysfunction | Yes | 0 | No | 0 | None | Mild | 1.42 | 40 | 1.02 | 22 | TPE, then ECZ | CR | No |
| 9 | M | MPGN | KTx in father | 31 | Living | C3G | 31 | 3 | Proteinuria | No | 0 | No | 0 | None | Mild | 1.33 | 109 | 1.36 | 121 | TPE with steroids | NR | Yes |
| 10 | F | C3G | None | 45 | Living | C3G | 45 | 3 | Graft dysfunction | No | 0 | Yes | 0 | None | None | 1.90 | 66 | NA | 3 | Steroids and ECZ | CR | No |
C3GN: C3 glomerulonephritis; DDD: dense deposit disease; ECZ: eculizumab; F: female; M: male; MPGN: membranoproliferative glomerulonephritis; NA: not available; NR: no remission; SCr: serum creatinine; TPE: therapeutic plasma exchange.