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MRD surveillance precedes imaging. (A) Swimmer plot depicting MRD surveillance and tumor events. (B) Density curve in 5 patients indicating the peak of positive ctDNA occurred 2.7 months earlier than that of imaging examinations. (C) Negative ctDNA results helped differentiate pulmonary nodules (red circle) in case 18. (D) ctDNA quantification in case 10 reflected treatment efficacy.
