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. 2024 Jun 17;10(12):e33132. doi: 10.1016/j.heliyon.2024.e33132

Fig. 6.

Fig. 6

The ERK inhibitor U0126 abrogated the changes in mitochondrial homeostasis and cell autophagy in HTR-8/SVneo cells induced by HTR1B overexpression. (A–B) WB were performed to examine the protein levels of P-ERK/ERK in HTR-8/SVneo cells exposed to different concentrations of U0126 (1 μM, 2 μM, 5 μM, and 10 μM). GAPDH served as a loading control. (C–E) The protein levels of T-ERK and P-ERK in HTR-8/SVneo cells exposed to 10 μM U0126. (F–K) The protein levels of SDHA, OPA1, Fis1, Beclin1, and the ratio of LC3II/I in HTR-8/SVneo cells exposed to 10 μM U0126. Data are shown as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.