Fig. 7.

This schematic representation illustrates the impact of HTR1B on mitochondrial homeostasis and mitophagy through the activation of the ERK/MAPK signalling pathway during post-implantation embryonic development. HTR1B upregulates the MAPK pathway, leading to mitochondrial dyshomeostasis, excessive mitophagy, and subsequent effects on cell viability and proliferation. Treatment with the ERK inhibitor U0126 rescues mitochondrial dyshomeostasis and excessive mitophagy.