Table 1.

Inclusion and exclusion criteria.

Inclusion criteria	Exclusion criteria	Dropout criteria
– Competent to give written informed consent – Signed consent—age ≥18 years – Diagnosis of MS (27), NMOSD (28), and MOGAD (23) – Expanded Disability Status Scale (EDSS) assessment score ranging from 0 to 6.5 (inclusive) at baseline	– History of drug or alcohol abuse – Evidence of active systemic infection – Optic neuritis within 3 months prior to the baseline assessment – Any steroid treatment within the preceding month – Pregnancy – Inability to cooperate	– Patient’s withdrawal of consent – Lost to follow-up – Non−compliance with protocol (decision by study board) – Condition hindering study continuation (decision by the study board)

Exclusion criteria are only considered at baseline, while dropout criteria are checked at each follow−up visit.