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. 2024 Jul 16;29:366. doi: 10.1186/s40001-024-01936-y

Table 6.

Association of BRCA mutation and HRD status with pCR (RCB 0) from clinical cohort

All patients (n = 50) pCR n (%) Non- pCR n (%) OR 95% CI Logistic P value
BRCA status
 Non-mutated 5 (14) 30 (86) 1
 Mutated 6 (40) 9 (60) 4.0 0.99–16.24 0.052
HRD status
 Negative 1 (5) 19 (95) 1
 Positive 10 (33) 20 (67) 9.5 1.11–81.5 0.040
BRCA wild-type (n = 35)
 HRD negative 1 (5) 19 (95) 1
 HRD positive 4 (27) 11 (73) 6.91 0.68–69.86 0.102

HRD positive = HRD score ≥ 10 for AcornHRD or BRCA mutation

HRD negative = HRD score < 10 for AcornHRD