Fig. 5.

From left to right, Kaplan Meier survival curves based on a established gene-expression endotype (A in red vs. B in blue); Patients with Endotype A had a higher hazard of 28-day mortality compared to Endotype B (HR 3.7 (95% CI 1.5, 8.7), p = 0.003), b latent profile phenotype (Phenotype 1 in orange and Phenotype 2 in brown); Patients with Phenotype 1 had a higher hazard of 28-day mortality compared to those belonging to Phenotype 2 (HR 4.5 (95% CI 1.9, 10.6), p < 0.001). c Integrated subclass assignment scheme that considered both the endotype and phenotype assignment among patients including all four possible combinations: (i) Endotype A/Phenotype 1 (deep purple), (ii) Endotype B/Phenotype 1 (deep plum), (iii) Endotype A/Phenotype 2 (light magenta), (iv) Endotype B/Phenotype 2 (orange). Patients assigned as both Endotype B and Phenotype 2 had the lowest mortality risk. Compared to this group, patients classified as Endotype A & Phenotype 1 had a higher hazard of mortality (HR 12.5 (95% CI 3.8, 41.2), p < 0.001). Patients classified as Endotype B & Phenotype 1 had a hazard ratio of mortality of 4.8 (95% CI 1.1, 20.1, p = 0.032). Patients classified as Endotype A & Phenotype 2 had a hazard ratio of mortality of 3.6 (95% CI 1.2, 11.1), p = 0.024. There were no statistically significant differences between the latter two groups