Table 2.

Logistic regression analyses to test association between latent profile phenotypes across derivation and validation sets and pediatric septic shock outcomes

Variable	Unadjusted OR	Adjusted OR*	p value
Complicated Course
Phenotype 1 (relative to Phenotype 2)	4.8 (3.5, 6.6)	3.9 (2.8, 5.5)	< 0.001
7-day mortality
Phenotype 1 (relative to Phenotype 2)	6.7 (4.4, 10.2)	5.6 (3.6, 8.6)	< 0.001
28-day mortality
Phenotype 1 (relative to Phenotype 2)	5.6 (3.9, 8.1)	4.4 (3.0, 6.5)	< 0.001

*All models adjusted for era of enrollment (2013–2023 vs. 2003–2013), age, PRISM III illness severity score, co-morbidity, and immunocompromised status