Table 1.
Demographic features, metabolic health, and oxidative-stress-related markers of the MARK-AGE study population
| Parameters | n | Range | Mean (SD) |
|---|---|---|---|
| UCB (μmol/L) | 2489 | 0.7–36.3 | 6.393 (3.61) |
| Subject Groups | |||
| RASIG | 1779 | 0.7–36.3 | 6.571 (3.73) |
| GO | 447 | 1.7–25.5 | 6.083 (3.36) |
| SGO | 263 | 1.1–18.5 | 5.716 (2.99) |
| Sex | |||
| Female | 1361 | 1.1–36.3 | 5.814 (3.20) |
| Male | 1128 | 0.7–32.4 | 7.092 (3.93) |
| Age (years) | 2489 | 31.6–80.9 | 58.49 (10.6) |
| BMI (kg/m2) | 2489 | 15.8–48.9 | 26.31 (4.43) |
| Weight (kg) | 2489 | 42–135 | 75.15 (14.8) |
| Height (cm) | 2489 | 141–200 | 168.8 (9.41) |
| WC (cm) | 2489 | 52–152 | 92.62 (12.5) |
| WHR | 2489 | 0.5–1.27 | 0.907 (0.08) |
| Heart rate (bpm) | 2489 | 38–153 | 70.18 (11.1) |
| BP diastolic (mmHg) | 2489 | 51–137 | 81.00 (11.0) |
| BP systolic (mmHg) | 2489 | 80–270 | 136.0 (20.1) |
| Left hand power (kg) | 2478 | 0–72 | 32.79 (10.8) |
| Right hand power (kg) | 2485 | 0–100 | 34.30 (11.1) |
| HbA1c (%) | 2470 | 4.6–13.1 | 6.043 (0.59) |
| Insulin (μU/mL) | 2487 | 0–65.2 | 6.128 (4.77) |
| Triglycerides (mmol/L) | 2326 | 0.2–12.0 | 1.271 (0.87) |
| Cholesterol (mmol/L) | 2327 | 2.0–11.2 | 5.609 (1.03) |
| HDL cholesterol (mmol/L) | 2360 | 0.5–3.7 | 1.537 (0.44) |
| LDL cholesterol (mmol/L) | 2361 | 0.5–8.3 | 3.331 (0.87) |
| Adiponectin (ng/mL) | 2487 | 1.9–64.5 | 14.35 (7.65) |
| FRS (points) | 2246 | −1–23 | 12.98 (4.17) |
| ALT (U/l) | 2487 | 5–100 | 24.18 (10.3) |
| γ-GT (U/l) | 2346 | 0–362 | 22.36 (28.0) |
| Ascorbic acid (mg/L) | 2489 | 0.05–62.3 | 5.177 (3.65) |
| Uric acid (mg/L) | 2489 | 13.1–109 | 45.45 (12.0) |
| Glutathione (μmol/L) | 2488 | 435–2090 | 1107 (196) |
| Cysteine (μmol/L) | 2488 | 39.4–291 | 143.9 (33.4) |
| MDA (μmol/L) | 2489 | 0–3.7 | 0.322 (0.23) |
| Protein carbonyls (nmol/mg) | 2489 | 0.3–2.8 | 0.582 (0.10) |
| 3-Nitrotyrosine (pmol/mg) | 2470 | 0.1–27 | 4.491 (2.80) |
| Urinary 8-isoprostane (ng/mL) | 2480 | 0.1–40.2 | 2.316 (2.32) |
| Plasma creatinine (μmol/L) | 2487 | 30.5–241 | 74.04 (15.9) |
| Urinary creatinine (pmol/L) | 2480 | 0.6–46.2 | 10.35 (5.83) |
| CRP (mg/L) | 2487 | 0–40.9 | 2.199 (3.27) |
| Arg-Pyr (%) | 2441 | 0.0003–19.2 | 0.313 (0.78) |
| CML (%) | 2441 | 0.0003–9.97 | 0.275 (0.80) |
Data are presented as mean ± standard deviation. The means are in bold to make them stand out.
UCB, unconjugated bilirubin; RASIG, randomly recruited age-stratified individuals from the general population; GO, GEHA (genetics of healthy aging) offspring; SGO, spouses of GO (GEHA offspring); FRS, Framingham Risk Score; ALT, alanine aminotransferase; γ-GT, gamma-glutamyl transferase; MDA, malondialdehyde; CRP, C-reactive protein; Arg-Pyr, arg-pyrimidine; CML, carboxymethyllysine.