Table 4.
Differences in biomarkers between Class1 vs. Class10, in two age subgroups (</≥ 50 years)
| Parameter | Age <50 years (N = 130) |
Age ≥50 years (N = 366) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Class 1 |
Class 10 |
p-Value | Class 1 |
Class 10 |
p-Value | |||||
| N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | N | Mean (SD) | |||
| UCB (μmol/L) | 58 | 2.434 (0.48) | 72 | 14.91 (4.17) | <0.001 | 190 | 2.488 (0.41) | 176 | 14.50 (3.96) | <0.001 |
| Age (years) | 58 | 43.06 (4.54) | 72 | 42.70 (4.20) | 0.606 | 190 | 62.79 (6.77) | 176 | 64.48 (6.57) | 0.015 |
| BMI (kg/m2) | 58 | 25.95 (4.42) | 72 | 24.11 (3.71) | 0.008 | 190 | 27.47 (5.33) | 176 | 26.30 (4.23) | 0.088 |
| Weight (kg) | 58 | 73.17 (16.9) | 72 | 73.32 (15.8) | 0.84 | 190 | 75.79 (16.1) | 176 | 77.24 (14.9) | 0.214 |
| Height (cm) | 58 | 167.2 (9.15) | 72 | 173.7 (10.2) | <0.001 | 190 | 166.0 (8.50) | 176 | 171.1 (9.40) | <0.001 |
| WC (cm) | 58 | 89.53 (13.1) | 72 | 87.18 (11.6) | 0.165 | 190 | 95.47 (13.5) | 176 | 94.86 (11.7) | 0.923 |
| WHR | 58 | 0.886 (0.08) | 72 | 0.885 (0.07) | 0.938 | 190 | 0.915 (0.07) | 176 | 0.931 (0.07) | 0.039 |
| Heart rate (bpm) | 58 | 75.57 (10.6) | 72 | 67.75 (12.2) | <0.001 | 190 | 72.28 (11.0) | 176 | 68.87 (10.9) | 0.002 |
| BP diastolic (mmHg) | 58 | 80.59 (11.5) | 72 | 76.29 (8.77) | 0.033 | 190 | 81.98 (10.5) | 176 | 83.30 (10.3) | 0.27 |
| BP systolic (mmHg) | 58 | 126.3 (16.6) | 72 | 124.3 (13.9) | 0.486 | 190 | 139.8 (21.3) | 176 | 141.5 (20.6) | 0.395 |
| Left hand power (kg) | 58 | 34.84 (10.5) | 72 | 38.50 (10.2) | 0.036 | 186 | 30.28 (10.7) | 175 | 35.01 (10.8) | <0.001 |
| Right hand power (kg) | 58 | 36.12 (10.6) | 72 | 40.01 (11.1) | 0.041 | 190 | 31.53 (10.7) | 176 | 36.39 (10.6) | <0.001 |
| HbA1c (%) | 58 | 5.979 (0.45) | 72 | 5.848 (0.41) | 0.082 | 185 | 6.189 (0.80) | 173 | 5.948 (0.50) | 0.002 |
| Insulin (μU/mL) | 58 | 7.093 (5.67) | 72 | 4.696 (2.65) | <0.001 | 189 | 7.548 (6.15) | 176 | 5.171 (2.91) | <0.001 |
| Triglycerides (mmol/L) | 55 | 1.582 (1.67) | 67 | 0.988 (0.60) | 0.014 | 178 | 1.449 (1.32) | 161 | 1.160 (0.54) | 0.127 |
| Cholesterol (mmol/L) | 55 | 5.492 (1.06) | 67 | 5.216 (0.82) | 0.179 | 178 | 5.635 (0.93) | 161 | 5.443 (1.13) | 0.085 |
| HDL cholesterol (mmol/L) | 57 | 1.373 (0.44) | 68 | 1.507 (0.34) | 0.014 | 180 | 1.463 (0.46) | 163 | 1.536 (0.47) | 0.117 |
| LDL cholesterol (mmol/L) | 57 | 3.344 (0.90) | 68 | 3.061 (0.77) | 0.063 | 180 | 3.409 (0.82) | 163 | 3.199 (0.93) | 0.008 |
| Adiponectin (ng/mL) | 58 | 12.94 (8.52) | 72 | 13.16 (5.86) | 0.155 | 190 | 15.03 (8.73) | 175 | 15.20 (8.68) | 0.787 |
| FRS (points) | 53 | 10.70 (3.97) | 61 | 6.660 (4.08) | <0.001 | 167 | 14.93 (2.85) | 150 | 13.77 (2.79) | <0.001 |
| ALT (U/l) | 58 | 23.12 (10.9) | 72 | 23.06 (9.11) | 0.922 | 189 | 23.87 (10.3) | 176 | 23.85 (9.14) | 0.66 |
| γ-GT (U/l) | 56 | 25.72 (38.2) | 65 | 15.73 (14.9) | 0.047 | 180 | 24.00 (31.9) | 163 | 24.06 (30.2) | 0.413 |
| Ascorbic acid (mg/L) | 58 | 5.354 (3.95) | 72 | 4.692 (2.86) | 0.616 | 190 | 5.689 (5.41) | 176 | 4.682 (2.94) | 0.102 |
| Uric acid (mg/L) | 58 | 42.27 (13.6) | 72 | 44.13 (13.6) | 0.349 | 190 | 44.10 (11.6) | 176 | 47.82 (12.0) | 0.002 |
| Glutathione (μmol/L) | 58 | 1065 (225) | 72 | 1104 (176) | 0.357 | 190 | 1099 (181) | 176 | 1146 (210) | 0.044 |
| Cysteine (μmol/L) | 58 | 123.1 (33.7) | 72 | 126.7 (27.1) | 0.532 | 190 | 149.7 (37.8) | 176 | 143.0 (31.1) | 0.186 |
| MDA (μmol/L) | 58 | 0.292 (0.20) | 72 | 0.287 (0.19) | 0.955 | 190 | 0.318 (0.23) | 176 | 0.336 (0.20) | 0.104 |
| Protein carbonyls (nmol/mg) | 58 | 0.596 (0.30) | 72 | 0.595 (0.09) | 0.024 | 190 | 0.588 (0.10) | 176 | 0.585 (0.08) | 0.8 |
| 3-Nitrotyrosine (pmol/mg) | 57 | 4.493 (2.45) | 72 | 4.532 (2.67) | 0.957 | 185 | 4.603 (3.19) | 174 | 4.319 (2.26) | 0.876 |
| Urinary 8-isoprostane (ng/mL) | 58 | 2.064 (0.85) | 72 | 2.042 (1.02) | 0.379 | 188 | 3.151 (3.98) | 175 | 2.060 (1.43) | <0.001 |
| Plasma creatinine (μmol/L) | 58 | 66.67 (13.8) | 72 | 78.39 (14.2) | <0.001 | 189 | 71.60 (20.0) | 176 | 78.49 (16.0) | <0.001 |
| Urinary creatinine (pmol/L) | 58 | 10.43 (5.94) | 72 | 11.86 (6.50) | 0.179 | 188 | 9.402 (5.43) | 175 | 11.02 (5.89) | 0.008 |
| CRP (mg/L) | 58 | 1.996 (2.27) | 72 | 1.827 (4.36) | 0.004 | 189 | 2.870 (3.45) | 176 | 2.186 (3.91) | 0.015 |
| Arg-Pyr (%) | 58 | 0.280 (0.62) | 71 | 0.288 (0.39) | 0.215 | 184 | 0.253 (0.21) | 171 | 0.452 (1.51) | 0.135 |
| CML (%) | 58 | 0.155 (0.14) | 71 | 0.188 (0.46) | 0.153 | 184 | 0.203 (0.49) | 171 | 0.280 (0.99) | 0.754 |
Data are presented as mean ± standard deviation.
UCB, unconjugated bilirubin; RASIG, randomly recruited age-stratified individuals from the general population; GO, GEHA (genetics of healthy aging) offspring; SGO, spouses of GO (GEHA offspring); FRS, Framingham Risk Score; ALT, alanine aminotransferase; γ-GT, gamma-glutamyl transferase; MDA, malondialdehyde; CRP, C-reactive protein; Arg-Pyr, arg-pyrimidine; CML, carboxymethyllysine.