Fig 6.

In vivo cross-protection studies. Mice were dosed with 5 mg/kg of mAb or bsAb as indicated and then challenged intranasally with 5× LD₅₀ of diverse viruses: H3N2 (A/Philippines/2/1982; A/PR/8/1934 reassortant X-79), B/Malaysia/2506/2004 (B/Victoria/2/87-like), H5N1 1G01 EMV (A/Vietnam/1203/2004-low pathogenic 6:2 A/PR/8/1934 reassortant strain), and H5N1 (A/Vietnam/1203/2004-low pathogenic 6:2 A/PR/8/1934 reassortant strain). Experiments were performed with n = 5 per group. An irrelevant Sudan virus-specific mAb (F4) was used as a control.