Fig. 6.

Treatment with mussel oligosaccharide (MOS-1) reverses liver steatosis in mice fed a high-fat diet (HFD). (A) Time chart of animal experiment with gavage of MOS-1. (B) Representative hematoxylin and eosin (H&E) stains of mouse liver tissue sections. The black frame indicates the area shown in enlarged form in the bottom panelslack arrows indicate lipid droplets or microvesicular steatosis. (C) HFD-fed apolipoprotein E (ApoE)^−/− mice were sacrificed after treatment with MOS-1 or vehicle control for two weeks, and values associated with liver status were determined according to standard methods. (n = 10 animals per group). ∗^∗P < 0.05, ^∗∗P < 0.01, ^∗∗∗P < 0.001, and ^∗∗∗∗P < 0.0001; n.s.: no statistically significant. TG: triglyceride; ALT: serum alanine transaminase; AST: serum aspartate aminotransferase; ALP: serum alkaline phosphatase; BUN: blood urea nitrogen; Crea: creatinine.