Figure 1.

Prevalence of NAb positivity in global adult and pediatric participants by AAV serotype and serum dilution

(A) Heatmap of the prevalence of NAb activity for adult participants (n = 502). (B) Heatmap of the prevalence of NAb activity for pediatric participants (n = 50). Heatmaps show the prevalence of NAb activity against six AAV serotypes across all serum dilutions. Numbers inside squares indicate the percentage of serum samples positive for NAb activity against the designated serotype at the designated serum dilution (out of all samples tested for that AAV at that serum dilution). Gray squares indicate that all tested serum samples were negative for NAb activity against the serotype at the specified dilution. AAV, adeno-associated virus; Nab, neutralizing antibody.