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. 2024 May 29;32(3):101273. doi: 10.1016/j.omtm.2024.101273

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© 2024 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Prevalence of NAb positivity in adult participants by AAV serotype and serum dilution across geographical regions

Heatmaps show the prevalence of NAb activity against six AAV serotypes for adult participants (n = 502) across all serum dilutions on a per country basis, sorted by geographical region (green, North America; yellow, Europe; pink, Asia-Pacific). Numbers inside squares indicate the percentage of serum samples positive for NAb activity against the designated serotype at the designated serum dilution (out of all samples tested for that AAV at that serum dilution). Gray squares indicate that all tested serum samples were negative for NAb activity against the serotype at the specified dilution. AAV, adeno-associated virus; Nab, neutralizing antibody.