Table 2.

Variable importance in predicting AAV NAb titer from six AAVs and additional features using a random forest prediction model

Features	AAV1	AAV5	AAV6	AAV8	AAV9	AAV Rh74var
AAVRh74var	0.1903	0.2219	0.1547	0.6887	0.1853	–
AAV8	0.0595	0.2143	0.0694	–	0.4256	0.5435
AAV6	0.6791	0.2728	–	0.0683	0.0455	0.1015
AAV1	–	0.1397	0.6864	0.0649	0.0584	0.1621
AAV9	0.0268	0.0866	0.0321	0.0895	–	0.1373
AAV5	0.0189	–	0.0358	0.0593	0.1622	0.0212
Age	0.0024	0.0108	0.0017	0.0045	0.0497	0.0033
Fallopian tube cancer, malignant peritoneal neoplasm, ovarian cancer	0.0004	0.0063	0.0004	0.0039	0.0161	0.0004
North America region	0.0062	0.0021	0.0015	0.0008	0.0095	0.0062
Canada	0.0037	0.0017	0.0029	0.0010	0.0101	0.0069
Metastatic renal cell carcinoma	0.0009	0.0042	0.0021	0.0006	0.0016	0.0048
France	0.0029	0.0052	0.0008	0.0008	0.0009	0.0010
White ethnicity	0.0015	0.0014	0.0041	0.0010	0.0024	0.0008
UK	0.0002	0.0015	0.0002	0.0050	0.0036	0.0007
Ethnicity not reported	0.0016	0.0045	0.0009	0.0007	0.0013	0.0007
Asian ethnicity	0.0011	0.0018	0.0008	0.0008	0.0034	0.0016
Europe region	0.0005	0.0031	0.0005	0.0012	0.0026	0.0007
Male	0.0009	0.0010	0.0011	0.0006	0.0038	0.0005
South Korea	0.0000	0.0018	0.0001	0.0003	0.0044	0.0001
Ethnicity not Hispanic or Latino	0.0010	0.0018	0.0004	0.0004	0.0022	0.0009
Female	0.0002	0.0009	0.0004	0.0006	0.0034	0.0005

AAV, adeno-associated virus; Nab, neutralizing antibody.