TABLE 1.
Descriptive characteristics of the combined study sample and stratified by non‐Hispanic/Latino and Hispanic/Latino white participants.
| Parameter | All a | Non‐Hispanic/Latino White | Hispanic/Latino White b | Sig. (p) |
|---|---|---|---|---|
| N | 239 | 112 | 115 | |
| Age, years | 70.8 ± 7.8 | 71.9 ± 8.0 | 69.7 ± 7.3 | 0.04 |
| Sex, %female | 55.2 | 47.3 | 64.3 | 0.01 |
| Education, years | 15.6 ± 3.4 | 16.5 ± 3.3 | 14.9 ± 3.3 | <0.001 |
| APOE e4, %carrier | 38.0 | 38.3 | 40.7 | 0.45 |
| CDR‐SOB | 2.1 ± 2.6 | 2.0 ± 2.1 | 2.2 ± 3.0 | 0.60 |
| CDR Global | ||||
| 0 | 26.7 | 21.4 | 28.7 | 0.25 |
| 0.5 | 56.9 | 63.3 | 53.0 | |
| 1.0+ | 16.3 | 15.2 | 18.2 | |
| WMH burden (log) | 7.8 ± 1.0 | 7.8 ± 1.0 | 7.8 ± 0.9 | 0.11 c |
| Aβ‐PET | ||||
| Centiloids (CL) | 29.0 ± 40.6 | 29.6 ± 41.8 | 28.9 ± 36.2 | 0.90 |
| Visual read, %positive | 37.7 | 38.3 | 40.0 | 0.80 |
| Quantification, %positive (CL ≥ 25) | 42.2 | 40.2 | 45.2 | 0.44 |
| 3‐Level Aβ‐PET | 0.63 | |||
| Low Aβ‐PET (CL < 10), % | 46.4 | 48.2 | 42.6 | |
| Intermediate Aβ‐PET (CL 10–49), % | 23.8 | 21.4 | 26.1 | |
| High Aβ‐PET (CL > 49), % | 29.7 | 30.3 | 31.3 | |
| Plasma p‐tau217, pg/mL | 0.67 ± 0.50 | 0.67 ± 0.53 | 0.67 ± 0.49 | >0.99 |
Abbreviations: Aβ‐PET, beta‐amyloid positron emission tomography; APOE, apolipoprotein E; CDR (SOB), Clinical Dementia Rating Scale (Sum of Boxes); CL, Centiloids; pg/mL, picograms per milliliter; WMH, white matter hyperintensity.
N = 10 Black/African American and N = 2 Black/Hispanic were included in the combined cohort analyses, but detailed breakdown and within‐group analyses not provided due to low N.
Hispanic/Latino white participants by self‐reported country/region of origin: Cuban (49.6%), South American (35.7%), Puerto Rican (8.7%), Central American (3.5%), Other (1.7%), Dominican (<1%).
Analysis of covariance comparing Hispanic/Latino White and non‐Hispanic/Latino White on log transformed white matter hyperintensity burden controlling for age and total intracranial volume.