FIG. 5.

p21-mediated tumor growth inhibition. HeLa and SiHa cells (2.5 × 10⁶) were separately injected subcutaneously into the flanks of nude mice. When the tumors grew to about 75 mm³, the animals were reanesthetized and 2.5 × 10⁷ PFU of adenovirus encoding sense p21 or antisense p21 or PBS only (mock infection) was injected into the tumor in five nude mice in each cell line group. The volumes of the tumors in five nude mice in each group were measured weekly. The error bars indicate the standard deviations of tumor volumes of five mice.