Table 1.
Unweighted and weighted cohort characteristics using combined or non-combined regimens.
| Unweighted cohort | Weighted cohort | ||||||
|---|---|---|---|---|---|---|---|
| Overall (N = 647) [n (%)] | Combined (N=91) [n (%)] | Non-combined (N=556) [n (%)] | SMD | Combined (N=83.8) [n (%)] | Non-combined (N=86.6) [n (%)] | SMD | |
| Sex (Male) | 349 (53.9) | 49 (53.8) | 300 (54.0) | 0.002 | 45.2 (54.0) | 45.5 (52.5) | 0.029 |
| Age (years old) | 48.5 (14.0) | 48.3 (13.4) | 48.5 (14.0) | 0.017 | 48.4 (13.5) | 48.3 (14.1) | 0.003 |
| Body mass index (kg/m2) | 25.2 (3.5) | 24.8 (3.4) | 25.2 (3.5) | 0.107 | 24.8 (3.4) | 24.5 (3.5) | 0.060 |
| Hypertension | 103 (15.9) | 13 (14.3%) | 90 (16.2) | 0.053 | 12.5 (14.9) | 13.6 (15.7) | 0.022 |
| Diabetes mellitus | 48 (7.4) | 13 (14.3) | 35 (6.3) | 0.265 | 11.4 (13.6) | 12.1 (14.0) | 0.010 |
| Symptoms | |||||||
| Visual dysfunction | 543 (83.9) | 77 (84.6) | 466 (83.8) | 0.022 | 71.1 (85.0% | 71.7 (82.8) | 0.058 |
| Headache | 189 (29.2) | 12 (12.2%) | 177 (31.8) | 0.458 | 12.0 (14.3) | 12.0 (13.9) | 0.013 |
| Related with hypopituitarisma | 274 (42.3) | 49 (53.8) | 225 (40.5) | 0.270 | 44.8 (53.4) | 46.2 (53.3) | 0.003 |
| Other# | 39 (6.0) | 8 (8.8) | 31 (5.6) | 0.125 | 7.0 (8.4) | 7.3 (8.4) | <0.001 |
| Clinical functioning phenotype$ | 99 (15.3) | 11 (12.1) | 88 (15.8) | 0.108 | 9.7 (11.5) | 9.4 (10.8) | 0.022 |
| Treatment history | |||||||
| Medication history | 26 (4.0) | 3 (3.3) | 23 (4.1) | 0.044 | 2.3 (2.7) | 2.1 (2.5) | 0.017 |
| Radiotherapy history | 17 (2.6) | 1 (1.1) | 16 (2.9) | 0.128 | 1.0 (1.2) | 1.1 (1.3) | 0.009 |
| Surgical history | 127 (19.6) | 27 (29.7) | 100 (18.0) | 0.277 | 24.5 (29.2) | 26.4 (30.4) | 0.027 |
| Tumor volume (cm3) | 32.5 (24.6) | 45.1 (38.4) | 30.5 (20.9) | 0.474 | 40.9 (30.8) | 40.9 (29.1) | <0.001 |
| Maximal diameter (cm) | 0.331 | 0.023 | |||||
| ≥ 4 ＜ 4.5 | 268 (41.4) | 26 (28.6) | 242 (43.5) | 25.4 (30.3) | 26.9 (31.1) | ||
| ≥ 4.5 ＜ 5 | 159 (24.6) | 24 (26.4) | 135 (24.3) | 22.3 (26.7) | 23.3 (26.9) | ||
| ≥ 5 | 220 (34.0) | 41 (45.1) | 179 (32.2) | 36.1 (43.1) | 36.3 (42.0) | ||
| Knosp grade | 0.164 | 0.026 | |||||
| I-II | 195 (31.8) | 33 (36.3) | 173 (31.2) | 30.3 (36.2) | 31.3 (36.1) | ||
| III | 187 (28.9) | 27 (29.7) | 157 (28.2) | 22.8 (27.2) | 22.9 (26.4) | ||
| IV | 257 (39.7) | 31 (34.1) | 226 (40.6) | 30.7 (36.6) | 32.5 (37.5) | ||
| Tumor extension | |||||||
| Inferior - nasal sinus or clivus | 409 (63.2) | 58 (63.7) | 351 (63.1) | 0.013 | 52.1 (62.2) | 55.6 (64.2) | 0.043 |
| Superior - till the roof of 3rd Ventricle | 436 (67.4) | 55 (60.4) | 381 (68.5) | 0.170 | 50.9 (60.8) | 52.0 (60.1) | 0.015 |
| Superior - till lateral ventricle | 36 (5.6) | 6 (6.6) | 30 (5.4) | 0.050 | 5.1 (6.1) | 4.6 (5.3) | 0.033 |
| Posterior - interpeduncular cistern | 62 (9.6) | 15 (16.5) | 47 (8.5) | 0.245 | 10.9 (13.0) | 11.1 (12.8) | 0.005 |
| Anterior - planum sphenoidale | 156 (24.1) | 40 (44.0) | 116 (20.9) | 0.509 | 33.9 (40.5) | 35.0 (40.4) | 0.002 |
| Lateral | 255 (39.4) | 52 (57.1) | 203 (36.5) | 0.423 | 46.6 (55.7) | 49.1 (56.7) | 0.021 |
| Multilobular appearance | 362 (56.0) | 77 (84.6) | 285 (51.3) | 0.765 | 69.8 (83.3) | 72.3 (83.5) | 0.006 |
| Encasement of circle of Willis | 243 (37.6) | 53 (58.2) | 190 (34.2) | 0.497 | 47.8 (57.1) | 49.9 (57.6) | 0.009 |
a
: Fatigue, dizziness or loss of libido; #: incidental finding; $: Hyperprolactimia, acromegaly, Cushing’s disease or hyperthyroidism; SMD: standard mean difference