Fig. 3.

Domain structure of S. pyogenes SF370 spyDAC. Schematic representation of the domain structures of DisA in B. subtilis (BsuDisA, Accession No. P37573) and spyDAC in S. pyogenes (spyDAC, Accession No. Q99ZX0), respectively (A). The number represents amino acid residues. The percentages in parentheses between the two DAC domains indicate sequence identity and strong similarity. Sequence alignment of DisA and spyDAC (B). Notable functional motifs were annotated as DGA and RHR. Residues that bound the c-di-AMP or 3’-deoxyATP ligands were indicated (*). Colored residues were indicated in red (identical), green (strongly similar) and purple (somewhat similar).