Table 1.
Summary for the skin biophysical and clinical assessments.
| Timepoint | Placebo mean ± SD | n | p value change from baseline | AC treatment mean ±SD | n | p value change from baseline | p value treatment vs. placebo |
|---|---|---|---|---|---|---|---|
| Confocal fragmentation | |||||||
| Week 0 | 5.66 ± 1.32 | 52 | 5.81 ± 1.0 | 48 | |||
| Week 6 | 5.62 ± 1.27 | 51 | p=0.82 | 4.34 ± 1.19 | 47 | p < 0.01 | p < 0.01 |
| Week 12 | 5.65 ± 1.21 | 48 | p=0.98 | 3.22 ± 1.24 | 46 | p < 0.01 | p < 0.01 |
| Ultrasound HEP pixel count | |||||||
| Week 0 | 280.1 ± 380.2 | 52 | 303.5 ± 351.0 | 45 | |||
| Week 6 | 984.8 ± 712.8 | 49 | p < 0.01 | 1135.4 ± 804.5 | 44 | p < 0.01 | p=0.46 |
| Week 12 | 772.3 ± 545.9 | 51 | p < 0.01 | 1005.0 ± 765.5 | 47 | p < 0.01 | p=0.06 |
| Ultrasound LEP ratio | |||||||
| Week 0 | 1.07 ± 0.21 | 52 | 0.95 ± 0.26 | 46 | |||
| Week 6 | 0.97 ± 0.19 | 49 | p < 0.01 | 0.79 ± 0.19 | 44 | p < 0.01 | p < 0.01 |
| Week 12 | 0.99 ± 0.22 | 51 | p=0.05 | 0.86 ± 0.24 | 47 | p=0.04 | p=0.05 |
| Corneometer hydration | |||||||
| Week 0 | 52.9 ± 15.8 | 52 | 59.9 ± 13.7 | 48 | |||
| Week 6 | 51.1 ± 11.8 | 52 | p=0.26 | 64.4 ± 10.9 | 48 | p < 0.01 | p < 0.01 |
| Week 12 | 45.3 ± 11.0 | 52 | p < 0.01 | 68.2 ± 12.5 | 48 | p < 0.01 | p < 0.01 |
| Elasticity R2 | |||||||
| Week 0 | 0.668 ± 0.08 | 52 | 0.682 ± 0.10 | 48 | |||
| Week 6 | 0.683 ± 0.09 | 52 | p=0.215 | 0.823 ± 0.09 | 48 | p < 0.01 | p < 0.01 |
| Week 12 | 0.682 ± 0.09 | 52 | P=0.254 | 0.837 ± 0.11 | 48 | p < 0.01 | p < 0.01 |
| Profilometry Rz | |||||||
| Week 0 | 139.0 ± 10.6 | 52 | 136.9 ± 11.0 | 48 | |||
| Week 6 | 140.7 ± 10.8 | 52 | p=0.25 | 126.3 ± 9.9 | 48 | p < 0.01 | p < 0.01 |
| Week 12 | 144.1 ± 11.1 | 52 | p < 0.01 | 110.1 ± 8.4 | 48 | p < 0.01 | p < 0.01 |
| Glogau Scale | |||||||
| Week 0 | 2.56 ± 0.67 | 52 | 2.56 ± 0.65 | 48 | |||
| Week 6 | 2.56 ± 0.67 | 52 | n.c | 2.50 ± 0.62 | 48 | p=0.08 | p=0.07 |
| Week 12 | 2.56 ± 0.69 | 52 | n.c | 2.34 ± 0.64 | 48 | p < 0.01 | p < 0.01 |
| Skin even tone | |||||||
| Week 0 | 5.46 ± 1.29 | 52 | 5.60 ± 1.12 | 48 | |||
| Week 6 | 5.37 ± 1.25 | 52 | p=0.3 | 4.58 ± 1.09 | 48 | p < 0.01 | p < 0.01 |
| Week 12 | 5.21 ± 1.26 | 52 | p < 0.01 | 3.81 ± 1.08 | 48 | p < 0.01 | p < 0.01 |
Descriptive and probability statistics for the skin biophysical parameters and expert visual grading scales are presented. The table shows the mean and standard deviation for each measurement, with statistical significance for change from baseline, and for treatment vs placebo (at Week 6 and at Week 12). A threshold of p ≤ 0.05 was applied in all cases.