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. Author manuscript; available in PMC: 2024 Jul 18.
Published in final edited form as: Cell Rep. 2024 May 31;43(6):114302. doi: 10.1016/j.celrep.2024.114302

Figure 5. Macrophages modulate cardiac tissue β-adrenergic response.

Figure 5.

(A and B) Effect of isoproterenol challenge on hECT calcium transients shown through quantification of (A) beat rate and (B) average tau.

(C and D) Effect of 10 mM forskolin on hECT calcium transients shown through quantification of (C) beat rate and (D) average tau.

(E) Adrenaline and (F) norepinephrine production in −iM0 versus +iM0 hECTs.

(G) Mean active force production of tissues in response to treatment with β1-adrenergic receptor blocker bisoprolol hemifumarate.

Data represent mean ± SEM and were assessed via two-tailed t test for assessment of adrenaline and norepinephrine, or via repeated-measures two-way ANOVA with multiple comparisons comparing between conditions at each concentration of isoproterenol, forskolin, or bisoprolol respectively; *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.