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. 2024 Jul 3;631(8021):617–626. doi: 10.1038/s41586-024-07636-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Illustration of Gaussian components for no (S^0xACE2), one (S^1xACE2), two (S^2xACE2), or three (S^3xACE2) ACE2-bound spikes. S^1xRBD occupancy is the fraction of spikes bound by one ACE2 molecule and S^2xRBD occupancy is the fraction of spikes bound by two ACE2 molecules. b, Top row - S^1xRBD occupancy measured using mass photometry for different BA.2 spike mutants. Bottom row - S^2xRBD occupancy for different BA.2 spike mutants. c, Top row - S^1xRBD occupancy for different XBB.1.5 spike mutants. Bottom row - S^2xRBD occupancy for different XBB.1.5 spike mutants. Error bars in plots b-c indicate standard error between two biological replicates.