Table 1.

Inclusion and exclusion criteria for enrollment in the study.

Inclusion	Exclusion
Acutely deteriorating critically ill infant (<12 months) plus one or more of the following:	Current critical clinical status explained with a definitive diagnosis such as isolated prematurity, infection with normal response to treatment, trauma, and malignancy
Multi-system failure
Unexplained neurological findings
Unexplained metabolic abnormalities	Had a genetic diagnosis or clear indication of a specific syndrome
Malformations
Insufficient/abnormal response to standard therapy for an underlying condition	Parents declined to participate