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. 2024 Jun 24;47:161–175. doi: 10.1016/j.jot.2024.06.005

Figure 2.

Figure 2

Micro-CT analyses of femurs in Sp7fl/fl;Col1a1−Cre mice without neo at 10 weeks of age (A) Body weight of male and female Sp7fl/fl;Col1a1−Cre and the control (Sp7fl/+ and Sp7fl/fl) mice. (B–E) Three-dimensional trabecular bone architecture of the distal femoral metaphysis (B, C) and images of the cortical bone at the mid-diaphysis in the femurs (D, E) of male (B, D) and female (C, E) Sp7fl/fl and Sp7fl/fl;Col1a1−Cre mice. Scale bars: 1 mm. (F–I) Quantification of trabecular bone (F, G) and cortical bone (H, I) parameters in male (F, H) and female (G, I) Sp7fl/fl;Col1a1−Cre and the control (Sp7fl/+ and Sp7fl/fl) mice. n = 8 (4 male Sp7fl/+ and 4 Sp7fl/fl), n = 7 (male Sp7fl/fl;Col1a1−Cre), n = 17 (7 female Sp7fl/+ and 10 Sp7fl/fl), and n = 10 (female Sp7fl/fl;Col1a1−Cre). (J–M) High resolution micro-CT images of cortical bone at the mid-diaphysis in male femurs (J, K) and the quantification of cortical porosity (L, M). The percentage of the pore area in the cortical area is shown. n = 14 (Sp7floxneo/+), n = 11 (Sp7floxneo/floxneo), n = 12 (Sp7floxneo/floxneo;Col1a1−Cre), n = 4 (Sp7fl/fl), and n = 5 (Sp7fl/fl;Col1a1−Cre).