Table 2.
Heritability estimates for different models using all cancer types or PDAC as the dependent variable. Real scale is the observable scale of the trait versus the liability scale which is non-observable. Liability follows a standardized normal distribution that after a certain threshold triggers the illness
Dependent variable | Heritability | Liability scale | Real scale |
---|---|---|---|
All cancer types | Model I | 0.99 [0.98–0.99] | 0.55 [0.41–0.63] |
Model II | 0.39 [0.28–0.52] | 0.22 [0.15–0.29] | |
Model III | 0.21 [0.1–0.33] | 0.1 [0.04–0.16] | |
Only PDAC (Model III) | 500,000 iterations | 0.27 [0.06–0.47] | 0.07 [0.02–0.12] |
Only PDAC (Model III) | 600,000 iterations | 0.27 [0.07–0.47] | 0.07 [0.02–0.13] |