Table 2.
Lesion characteristics
| Overall, N = 95 | RFR > 0.89, N = 53 | RFR ≤ 0.89, N = 42 | p value | |
|---|---|---|---|---|
| RFR | 0.90 (0.87–0.95) | 0.94 (0.92–0.98) | 0.86 (0.82–0.88) | < 0.001 |
| CT-derived lesion characteristics | ||||
| Proximal lesion | 47 (49%) | 27 (51%) | 20 (48%) | 0.75 |
| Location | 0.030 | |||
| Left anterior descending | 61 (64%) | 27 (51%) | 34 (81%) | |
| Left circumflex | 24 (25%) | 18 (34%) | 6 (14%) | |
| Right coronary artery | 8 (8%) | 6 (11%) | 2 (5%) | |
| Left main | 2 (2%) | 2 (4%) | 0 (0%) | |
| Max. diameter stenosis, % | 50.68 (40.57–60.69) | 49.00 (37.35–58.91) | 51.73 (43.46–64.44) | 0.19 |
| Max. diameter stenosis, cat | 0.27 | |||
| 1–24% | 9 (10%) | 7 (13%) | 2 (5%) | |
| 25–49% | 36 (38%) | 21 (40%) | 15 (36%) | |
| 50–69% | 43 (45%) | 23 (43%) | 20 (48%) | |
| 70–99% | 7 (7%) | 2 (4%) | 5 (12%) | |
| Max. area stenosis, % | 76 (64–85) | 74 (61–83) | 77 (66–87) | 0.20 |
| Lesion length, mm | 10.85 (7.69–17.44) | 10.50 (7.50–13.31) | 13.30 (8.30–19.54) | 0.069 |
| Volume and composition | ||||
| Total volume, mm3 | 87.73 (45.75–164.33) | 85.39 (47.11–138.20) | 111.04 (45.16–191.81) | 0.37 |
| Dense calcium volume, mm3 | 51.44 (14.72–101.24) | 49.00 (13.17–65.36) | 59.52 (16.85–135.06) | 0.19 |
| Noncalcified plaque volume | 33.95 (21.12– 61.86) | 33.64 (21.52– 60.63) | 37.84 (20.23– 64.99) | 0.89 |
| Fibrotic plaque, mm3 | 23.75 (14.23–46.45) | 21.44 (14.27–44.85) | 29.64 (13.44–51.15) | 0.37 |
| Fibrofatty plaque, mm3 | 4.94 (2.47–9.12) | 5.15 (2.58–9.16) | 4.42 (2.44–8.98) | 0.65 |
| Necrotic core volume, mm3 | 3.17 (1.05–8.26) | 3.56 (0.88–8.14) | 2.44 (1.08–8.58) | 0.85 |
| Functional analysis | ||||
| CT-FFR | 0.85 (0.77–0.91) | 0.89 (0.85–0.94) | 0.76 (0.72–0.79) | < 0.001 |
| CT-FFR ≤ 0.80 | 35 (37%) | 2 (4%) | 33 (79%) | < 0.001 |
| Coronary inflammation | ||||
| PCAT density, HU | –83.91 (–90.37, –73.90) | –81.30 (–89.82, –70.76) | –84.96 (–90.95, –77.67) | 0.31 |
All data are mean ± standard deviation, median (Q1–Q3), or absolute number (percentage)
CT-FFR, computed tomography derived fractional flow reserve; PCAT, peri-coronary adipose tissue; RFR, resting full-cycle ratio