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. 2024 Jul 17;15(7):508. doi: 10.1038/s41419-024-06905-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — In epidermal stem cells, FOXM1 transcriptionally activates H1B. H1B binds to promotorial regions of differentiation-related genes, inhibiting their transcription. During clonal conversion epidermal stem cell gives rise to transient amplifying cells where the reduced expression of H1B leads to the derepression of differentiation-related genes. The figure was created with BioRender.com.