Fig. 4. GC, MPER, and base mAbs have non-overlapping epitopes.

Competition-binding ELISA assay. Numbers indicate the percent binding of the competing mAb in the presence of the first mAb, compared to binding of competing mAb in the presence of an irrelevant negative control mAb, DENV-2D22. Full, intermediate, or no competition was defined based on the reduction in percent binding to <33% (black boxes with white numbers), 33 to 66% (gray boxes with black numbers), or >66% (white boxes with red numbers), respectively. The assay was repeated three times with comparable results.