Figure 3.

Inhibiting CP-AMPARs at the spinal cord level attenuates pain hypersensitivity caused by FK506 treatment. A–C, Time course of the paw withdrawal thresholds in response to von Frey filaments (A), pressure (B), and noxious heat (C) stimuli in wild-type mice (n = 8 mice per group) after intrathecal administration of 5 µg IEM-1460 in mice treated systemically with vehicle or FK506 (3 mg/kg per day) for 7 d. Data are expressed as mean ± SEM (n = 8 mice per group). *p < 0.05, **p < 0.01 compared with the baseline within the same group (two-way ANOVA followed by Tukey's post hoc test).