Figure 6.

α2δ-1 has a pivotal role in postsynaptic CP-AMPARs of spinal dorsal horn neurons induced by FK506 treatment. A, B, Representative recording traces (A) and quantification (B) show the current–voltage relationship of AMPAR-EPSCs in lamina II VGluT2 neurons of wild-type (WT) mice treated with 5 µM FK506 plus 20 µM pregabalin (PGB, n = 16 neurons from 3 mice) and in lamina II neurons of Cacna2d1 knock-out (KO) mice treated with 5 µM FK506 (n = 15 neurons from 3 mice). C, Rectification index (I_{+50 mV}/I_{−50 mV}) of AMPAR-EPSCs in lamina II VGluT2 neurons of WT mice treated with FK506 plus pregabalin and in lamina II neurons of Cacna2d1 KO mice treated with 5 µM FK506. PGB, pregabalin. Data are mean ± SEM.