Table 7.

Replication in the RS of the Top miRNAs Associated With Each CVD Risk Factor in the FHS

CVD risk factor	miRNA	No. full	Effect size	SE	P value
Systolic blood pressure	miR‐365a‐3p*	1991	0.631	0.387	0.103
	miR‐193b‐3p	1991	3.498	0.940	0.000204
	miR‐20b‐5p*	1991	2.404	1.233	0.0513
	miR‐16‐5p*	1991	0.415	1.095	0.705
	miR‐25‐3p*	1991	0.156	1.048	0.882
Diastolic blood pressure	miR‐193b‐3p	1991	2.109	0.491	1.86E‐05
Total cholesterol	miR‐126‐3p	1999	0.0674	0.00921	3.80E‐13
	miR‐191‐5p*	1999	0.0171	0.00856	0.0454
	miR‐425‐3p*	1999	0.00474	0.00615	0.441
	miR‐425‐5p*	1999	0.00503	0.00829	0.544
	miR‐625‐3p*	1999	0.0115	0.00853	0.178
Fasting blood glucose	miR‐192‐5p*	1999	0.0166	0.00712	0.0200
	miR‐193a‐5p	1999	0.0704	0.00883	2.59E‐15
	miR‐193b‐3p	1999	0.0405	0.00864	3.03E‐06
	miR‐122‐5p	1999	0.00192	0.00483	7.26E‐05
	miR‐365a‐3p*	1999	0.00480	0.00356	0.178
Body mass index	miR‐122‐5p*	1958	0.246	0.108	0.0230
	miR‐193b‐3p*	1958	0.133	0.194	0.492
	miR‐193a‐5p	1958	1.626	0.195	1.59E‐16
	miR‐365a‐3p*	1958	0.0181	0.0789	0.818
	miR‐101‐3p*	1958	−0.349	0.226	0.123
Current cigarette smoking	miR‐150‐5p	1971	0.178	0.0344	2.31E‐07
	miR‐152‐3p*	1971	0.0937	0.0375	0.0126
	miR‐125a‐5p	1971	0.0951	0.0245	0.000111
	miR‐34a‐5p	1971	0.134	0.0424	0.00155
	miR‐584‐5p*	1971	−0.0372	0.0776	0.631

Associations after adjustment for age, sex, subcohort, smoking status, and lipid levelsCVD indicates cardiovascular disease; FHS, Framingham Heart Study; miRNAs, microRNAs; and RS, Rotterdam Study.

^*Association does not replicate in the RS.