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. 2024 Jun 6;13(12):e032971. doi: 10.1161/JAHA.123.032971

Figure 4. Hemodynamic parameters, fibrosis, and cardiac tissue perfusion in CKD rats are improved by finerenone after 12 weeks.

Figure 4

SBP (A); LVESP (B); LVESPVR (C); LVEDP (D); LVEDPVR (E); and tau (F). Representative light microphotographs (20× magnification) of rat kidney sections stained with Sirius red (G) and kidney fibrosis (H). Septum tissue perfusion (I) (Protocol 2). ANOVA was used for statistical analysis, n=7–9. *P<0.05, **P<0.001, ***P<0.0001. CKD indicates chronic kidney disease; Fine, finerenone; LVEDP, left ventricular end‐diastolic pressure; LVEDPVR, left ventricular end‐diastolic pressure–volume relationship; LVESP, left ventricular end‐systolic pressure; LVESPVR, left ventricular end‐systolic pressure–volume relationship; and SBP, systolic blood pressure.