Table 1.
CKD by 5/6 Nephrectomy Induces Cardiovascular Alterations After 1 Month (Protocol 1)
| Sham (n=8) | CKD (n=7) | |
|---|---|---|
| BUN, mg/dL | 17±0.9 | 36±1.8* |
| Creatinine, μmol/L | 0.55±0.03 | 0.61±0.03 |
| SBP, mm Hg | 139±3 | 156±9 |
| LVESP, mm Hg | 128±5 | 154±12 |
| dP/dtmax, mm Hg/s | 9653±456 | 10 819±716 |
| LVESPVR, RVU/mm Hg | 24±1.0 | 25±2.0 |
| LVEDP, mm Hg | 5.3±0.4 | 7.4±0.9 |
| dP/dtmin, mm Hg/s | 10 545±437 | 13735±730* |
| τ, ms | 9.2±0.1 | 9±0.3 |
| LVEDPVR, RVU/mm Hg | 1.5±0.2 | 2.6±0.2* |
| HR, bpm | 359±9 | 364±12 |
Data are presented as the mean±SEM; n=7–8. Student's t test was used for statistical analysis. BUN indicates blood urea nitrogen; CKD, chronic kidney disease; HR, heart rate; LVEDP, left ventricular end‐diastolic pressure; LVEDPVR, left ventricular end‐diastolic pressure–volume relationship; LVESP, left ventricular end‐systolic pressure; LVESPVR, left ventricular end‐systolic pressure volume relationship; SBP, systolic blood pressure; and τ, time constant of relaxation.
*
P<0.05 vs sham.