Table 2.
CKD by 5/6 Nephrectomy Induces Cardiovascular Alterations After 3 Months (Protocol 2)
| Sham (n=8) | CKD (n=9) | CKD+finerenone (n=7) | |
|---|---|---|---|
| GFR, mL/min per 100 g of body weight | 1.07±0.08 | 0.46±0.07* | 0.54±0.08 |
| Albuminuria, mg/24 h | 305±19 | 446±39* | 346±44 |
| SBP, mm Hg | 150±3 | 168±8 | 146±6 |
| LVESP, mm Hg | 135±5 | 144±8 | 141±6 |
| dP/dtmax, mm Hg/s | 10 535±658 | 10 501±421 | 10.106±781 |
| LVESPVR, RVU/mm Hg | 26.3±0.6 | 27.9±1.0* | 26.4±1.1† |
| LVEDP, mm Hg | 5.1±0.4 | 9.0±0.9* | 7.1±0.4 |
| dP/dtmin, mm Hg/s | 11 148±559 | 12178±1410* | 13 358±1236 |
| τ, ms | 9.6±0.3 | 11.1±0.5 | 9.2±0.6† |
| LVEDPVR, RVU/mm Hg | 1.1±0.1 | 4.4±0.4* | 1.9±0.2† |
| HR, bpm | 368±6 | 364±10 | 371±7 |
ANOVA was used for statical analysis, Data are presented as the mean±SEM; n=7–9. CKD indicates chronic kidney disease; GFR, glomerular filtration rate; HR, heart rate; LVEDP, left ventricular end‐diastolic pressure; LVEDPVR, left ventricular end‐diastolic pressure volume relationship; LVESP, left ventricular end‐systolic pressure; LVESPVR, left ventricle end‐systolic pressure volume relationship; SBP, systolic blood pressure; and τ, time constant of relaxation.
*
P<0.05 vs sham.
†
P<0.05 vs CKD.