Table 2.
Distribution of the number of 15 HPV genotypesa detected by cervical swab and biopsy specimens using LiPA-25 and other 7 assays.
| Methods | No. of samples | 0 type (%) | All positive (%) | Single type (%) | Multiple types (%) |
Pb | |||
|---|---|---|---|---|---|---|---|---|---|
| ≥ 2 types | 2 types (%) | 3 types (%) | ≥ 4 types (%) | ||||||
| Swab | |||||||||
| LiPA-25 | 1,726 | 725 (42.0) | 1,001 (58.0) | 664 (38.5) | 337 (19.5) | 269 (15.6) | 55 (3.2) | 13 (0.7) | |
| Bohui-24 | 1,725 | 847 (49.1) | 878 (50.9) | 571 (33.1) | 307 (17.8) | 224 (13.0) | 70 (4.1) | 13 (0.7) | 0.587 |
| Yaneng-23 | 1,719 | 790 (46.0) | 929 (54.0) | 631 (36.7) | 298 (17.3) | 228 (13.2) | 60 (3.5) | 10 (0.6) | 0.490 |
| Tellgen-27 | 1,697 | 846 (49.9) | 851 (50.1) | 557 (32.8) | 294 (17.3) | 222 (13.1) | 56 (3.3) | 16 (0.9) | 0.706 |
| Hybribio-16 | 1,710 | 799 (46.7) | 911 (53.3) | 605 (35.4) | 306 (17.9) | 235 (13.8) | 60 (3.5) | 11 (0.6) | 1.000 |
| Hybribio-23 | 1,715 | 748 (43.6) | 967 (56.4) | 615 (35.9) | 352 (20.5) | 254 (14.8) | 77 (4.5) | 21 (1.2) | 0.221 |
| Bioperfectus-21 | 1,726 | 710 (41.1) | 1,016 (58.9) | 596 (34.6) | 420 (24.3) | 287 (16.6) | 107 (6.2) | 26 (1.5) | < 0.001 |
| Sansure-26 | 1,726 | 640 (37.1) | 1,086 (62.9) | 620 (35.9) | 466 (27.0) | 298 (17.3) | 121 (7.0) | 47 (2.7) | < 0.001 |
| Biopsy | |||||||||
| LiPA-25 | 56 | 4 (7.1) | 52 (92.9) | 52 (92.9) | 0 (0) | 0 (0) | 0 | 0 | |
| Bohui-24 | 56 | 6 (10.7) | 50 (89.3) | 50 (89.3) | 0 (0) | 0 (0) | 0 | 0 | - |
| Yaneng-23 | 56 | 4 (7.1) | 52 (92.9) | 49 (87.5) | 3 (5.4) | 3 (5.4) | 0 | 0 | 0.118 |
| Tellgen-27 | 56 | 3 (5.4) | 53 (94.6) | 51 (91.0) | 2 (3.6) | 2 (3.6) | 0 | 0 | 0.495 |
| Hybribio-16 | 56 | 3 (5.4) | 53 (94.6) | 49 (87.5) | 4 (7.1) | 4 (7.1) | 0 | 0 | 0.118 |
| Hybribio-23 | 56 | 3 (5.4) | 53 (94.6) | 47 (83.9) | 6 (10.7) | 5 (8.9) | 1 (1.8) | 0 | 0.027 |
| Bioperfectus-21 | 56 | 4 (7.1) | 52 (92.9) | 49 (87.5) | 3 (5.4) | 3 (5.4) | 0 | 0 | 0.118 |
| Sansure-26 | 56 | 2 (3.6) | 54 (96.4) | 45 (80.3) | 9 (16.1) | 9 (16.1) | 0 | 0 | 0.003 |
a
HPV types 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 66.
b
Chi-square test or Fisher's exact test, the difference between LiPA-25 and other 7 assays for the detection of single versus multiple genotypes (≥ 2 types).
Abbreviation: HPV, human papillomavirus.