Table 1.

Primary Mendelian randomization estimates of walking and sedentarism on EAA

Exposures	Outcomes	IVW		Weighted median		MR-Egger		RAPS
		Beta (95% CI)	P	Beta (95% CI)	P	Beta (95% CI)	P	Beta (95% CI)	P
Leisure sedentary behavior	GrimAge	0.780 (0.369,1.191)	< 0.001	1.100(0.488,1.711)	< 0.001	1.619(0− 0.337,3.575)	0.108	0.815(0.432,1.199)	< 0.001
	PhenoAge	0.387(− 0.137,0.912)	0.148	0.500(− 0.286,1.287)	0.213	1.963(− 0.533,4.459)	0.126	0.640(0.155,1.124)	0.010
	Horvath	0.114(− 0.329,0.556)	0.615	0.187(− 0.437,0.811)	0.557	0.090(− 2.020,2.200)	0.934	0.302(− 0.086,0.690)	0.127
	Hannum	− 0.137(− 0.598,0.323)	0.560	0.040(− 0.568,0.648)	0.896	1.532(− 0.640,3.703)	0.170	− 0.059(− 0.435, 0.317)	0.757
Usual walking pace	GrimAge	− 1.842(-2.937, − 0.747)	< 0.001	− 2.378(− 3.932, − 0.824)	0.003	− 2.256(− 6.979,2.467)	0.354	− 1.721(− 2.731, − 0.711)	< 0.001
	PhenoAge	− 1.567(− 3.052, − 0.082)	0.039	− 1.224(− 3.214, 0.766)	0.228	5.787(− 0.310,11.883)	0.069	− 1.261(− 2.722, − 0.178)	0.025
	Horvath	− 1.089(− 2.142, − 0.035)	0.043	− 0.777(− 2.270,0.715)	0.307	2.518(− 1.973,7.008)	0.277	− 1.105(− 2.131, − 0.079)	0.035
	Hannum	− 1.626(− 2.695,-0.557)	0.003	− 1.109(− 2.522,0.304)	0.124	− 1.336(− 5.931,3.259)	0.571	− 1.359(− 2.353, − 0.365)	0.007
	GrimAge	− 0.767(− 2.229,0.696)	0.304	− 0.129(− 1.946,1.688)	0.890	− 2.502(− 10.126,5.120) 0.536	− 0.719(− 2.010,0.573)	0.275
Duration of walks	PhenoAge	0.066(− 2.271,2.403)	0.956	0.826(− 1.734,3.386)	0.527	− 9.326(− 20.011,1.360) 0.121	− 0.133(− 1.748,1.483)	0.872
	Horvath	0.093(− 1.383,1.569)	0.901	0.848(− 0.932,2.628)	0.35	2.817(− 4.759,10.393)	0.49	− 0.150(− 1.456,1.155)	0.821
	Hannum	0.532(− 0.792,1.856)	0.431	0.445(− 1.317,2.207)	0.621	− 1.708(-8.352,4.936)	0.63	0.329(− 0.947,1.605)	0.613
Frequency of walking for pleasure in last 4 weeks	GrimAge	− 0.395(− 1.890,1.101)	0.605	− 0.375(0.637, − 1.932)	0.637	15.146(4.880,25.411)	0.03	− 0.244(–1.240,0.752)	0.631
	PhenoAge	− 0.619(− 1.933,0.696)	0.356	− 0.287(− 2.053,1.477)	0.749	1.700(− 11.238,14.638)	0.81	− 0.472(− 1.751,0.808)	0.470
	Horvath	0.333(− 0.722,1.388)	0.536	0.296(− 1.103,1.694)	0.679	2.266(− 8.150,12.677)	0.69	0.333(− 0.695,1.360)	0.526
	Hannum	0.224(− 0.803,1.251)	0.669	0.312(− 1.018,1.642)	0.646	6.531(− 3.621,16.683)	0.26	0.328(− 0.673,1.328)	0.521

CI Confident interval, IVW Inverse variance weighted, RAPS Robust Adjusted Profile Scores